Sioux Lookout offers nonstop service to 38 destinations, served by 2 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Red Lake | YRL | Canada | 171 km | 0h 40m | JV, WP |
| Cat Lake | YAC | Canada | 179 km | 0h 30m | |
| Pickle Lake | YPL | Canada | 190 km | 0h 35m | WP |
| Pikangikum | YPM | Canada | 238 km | 0h 45m | WP |
| Thunder Bay | YQT | Canada | 270 km | 1h 0m | JV, WP |
| North Spirit Lake | YNO | Canada | 274 km | 0h 55m | JV |
| Round Lake | ZRJ | Canada | 317 km | 1h 0m | JV |
| Keewaywin | KEW | Canada | 326 km | 1h 0m | WP |
| Deer Lake | YVZ | Canada | 336 km | 0h 50m | WP |
| Sandy Lake | ZSJ | Canada | 337 km | 1h 0m | JV, WP |
| Kingfisher Lake | KIF | Canada | 352 km | 1h 10m | WP |
| Muskrat Dam | MSA | Canada | 370 km | 1h 5m | WP |
| Summer Beaver | SUR | Canada | 371 km | 1h 10m | WP |
| Sachigo Lake | ZPB | Canada | 420 km | 1h 15m | JV |
| Bearskin Lake | XBE | Canada | 431 km | 1h 15m | WP |
| Big Trout | YTL | Canada | 434 km | 1h 15m | WP |
| Kasabonika | XKS | Canada | 440 km | 1h 15m | WP |
| Webequie | YWP | Canada | 446 km | 1h 15m | |
| Fort Severn | YER | Canada | 715 km | 2h 25m | WP |