Port Moresby Jacksons International offers nonstop service to 30 destinations, served by 6 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Popondetta | PNP | Papua New Guinea | 139 km | 0h 30m | CG, PX |
| Lae | LAE | Papua New Guinea | 322 km | 1h 10m | CG, PX |
| Alotau | GUR | Papua New Guinea | 355 km | 1h 0m | CG, PX |
| Goroka | GKA | Papua New Guinea | 423 km | 1h 5m | CG, PX |
| Daru | DAU | Papua New Guinea | 442 km | 1h 25m | CG, PX |
| Madang | MAG | Papua New Guinea | 493 km | 1h 15m | PX, CG |
| Mount Hagen | HGU | Papua New Guinea | 513 km | 1h 30m | CG, PX |
| Mendi | MDU | Papua New Guinea | 535 km | 1h 40m | CG |
| Wapenamanda | WBM | Papua New Guinea | 558 km | 1h 30m | PX |
| Hoskins | HKN | Papua New Guinea | 564 km | 1h 30m | CG, PX |
| Tari | TIZ | Papua New Guinea | 615 km | 1h 45m | CG, PX |
| Kiunga | UNG | Papua New Guinea | 749 km | 2h 10m | CG, PX |
| Wewak | WWK | Papua New Guinea | 757 km | 1h 20m | PX |
| Rabaul | RAB | Papua New Guinea | 802 km | 1h 25m | CG, PX |
| Tabubil | TBG | Papua New Guinea | 805 km | 2h 5m | CG, PX |
| Manus Island | MAS | Papua New Guinea | 817 km | 1h 20m | PX |
| Cairns | CNS | Australia | 837 km | 1h 30m | PX |
| Kavieng | KVG | Papua New Guinea | 856 km | 1h 30m | PX |
| Buka | BUA | Papua New Guinea | 935 km | 1h 40m | PX |
| Vanimo | VAI | Papua New Guinea | 993 km | 1h 40m | PX |
| Honiara | HIR | Solomon Islands | 1,409 km | 2h 20m | PX, IE |
| Brisbane | BNE | Australia | 2,082 km | 3h 10m | PX, QF |
| Sydney | SYD | Australia | 2,742 km | 3h 55m | PX, QF |
| Nadi | NAN | Fiji | 3,393 km | 4h 50m | PX |
| Manila | MNL | Philippines | 3,921 km | 5h 40m | PR, PX |
| Auckland | AKL | New Zealand | 4,124 km | 5h 0m | PX |
| Singapore | SIN | Singapore | 4,938 km | 6h 30m | PX |
| Hong Kong | HKG | Hong Kong SAR | 5,052 km | 6h 43m | PX |
| Tokyo | NRT | Japan | 5,055 km | 6h 50m | PX |
| Guangzhou | CAN | China | 5,179 km | 7h 10m | CZ |