Sam Ratulangi offers nonstop service to 16 destinations, served by 11 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Naha | NAH | Indonesia | 245 km | 1h 5m | IW |
| Gorontalo | GTO | Indonesia | 251 km | 1h 5m | IW |
| Ternate | TTE | Indonesia | 284 km | 1h 10m | IW, SJ |
| Kau | KAZ | Indonesia | 330 km | 1h 10m | IW |
| Luwuk | LUW | Indonesia | 372 km | 1h 30m | IW |
| Sorong | SOQ | Indonesia | 758 km | 1h 20m | JT, 8B |
| Ujung Pandang | UPG | Indonesia | 945 km | 1h 45m | JT, ID |
| Balikpapan | BPN | Indonesia | 945 km | 1h 40m | |
| Denpasar | DPS | Indonesia | 1,570 km | 2h 25m | 8B |
| Surabaya | SUB | Indonesia | 1,669 km | 2h 35m | JT |
| Jakarta | CGK | Indonesia | 2,200 km | 3h 10m | GA, ID, QG, QZ |
| Singapore | SIN | Singapore | 2,329 km | 3h 30m | TR |
| Shenzhen | SZX | China | 2,625 km | 3h 50m | 8B |
| Guangzhou | CAN | China | 2,723 km | 3h 58m | CZ, 8B |
| Shanghai | PVG | China | 3,292 km | 6h 40m | 8B |
| Kunming | KMG | China | 3,517 km | 5h 35m | 8L |