Sam Ratulangi offers nonstop service to 25 destinations, served by 10 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Gorontalo | GTO | Indonesia | 251 km | 1h 5m | IW |
| Ternate | TTE | Indonesia | 284 km | 1h 10m | 8B, IW, SJ |
| Luwuk | LUW | Indonesia | 372 km | 1h 30m | IW |
| Sorong | SOQ | Indonesia | 758 km | 1h 23m | 8B, JT |
| Balikpapan | BPN | Indonesia | 945 km | 1h 40m | |
| Ujung Pandang | UPG | Indonesia | 945 km | 1h 45m | ID, JT |
| Denpasar | DPS | Indonesia | 1,570 km | 2h 38m | 8B |
| Surabaya | SUB | Indonesia | 1,669 km | 2h 35m | JT |
| Jakarta | CGK | Indonesia | 2,200 km | 3h 10m | GA, ID, QG |
| Singapore | SIN | Singapore | 2,329 km | 3h 30m | TR |
| Shenzhen | SZX | China | 2,625 km | 3h 58m | 8B |
| Guangzhou | CAN | China | 2,723 km | 4h 15m | 8B, CZ |
| Seoul | ICN | Republic of Korea | 3,979 km | 5h 20m | ZE |