Sepinggan offers nonstop service to 46 destinations, served by 12 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| West Kutai | GHS | Indonesia | 172 km | 0h 45m | IW |
| Mamuju | MJU | Indonesia | 278 km | 1h 0m | IW |
| Palu | PLW | Indonesia | 337 km | 1h 15m | IW |
| Banjarmasin | BDJ | Indonesia | 339 km | 1h 15m | IW, QG |
| Palangkaraya | PKY | Indonesia | 345 km | 1h 15m | IW |
| Berau | BEJ | Indonesia | 382 km | 1h 5m | IW, SJ |
| Tarakan | TRK | Indonesia | 512 km | 1h 10m | QG |
| Ujung Pandang | UPG | Indonesia | 514 km | 1h 10m | ID, JT, QG |
| Bone | APD | Indonesia | 518 km | 1h 30m | KS |
| Malinau | LNU | Indonesia | 535 km | 1h 35m | IW |
| Bandar Seri Begawan | BWN | Brunei Darussalam | 720 km | 1h 30m | BI |
| Surabaya | SUB | Indonesia | 815 km | 1h 30m | IP, JT, QG |
| Praya | LOP | Indonesia | 832 km | 1h 35m | |
| Pontianak | PNK | Indonesia | 843 km | 1h 30m | ID |
| Denpasar | DPS | Indonesia | 849 km | 1h 45m | JT |
| Manado | MDC | Indonesia | 945 km | 1h 45m | |
| Semarang | SRG | Indonesia | 961 km | 1h 40m | JT |
| Yogyakarta | YIA | Indonesia | 1,056 km | 1h 50m | IP, JT, QG |
| Bandung | BDO | Indonesia | 1,208 km | 1h 55m | QG |
| Jakarta | CGK | Indonesia | 1,258 km | 2h 5m | GA, ID, IP, QG |
| Batam | BTH | Indonesia | 1,447 km | 2h 15m | |
| Singapore | SIN | Singapore | 1,466 km | 2h 25m | TR |
| Kuala Lumpur | KUL | Malaysia | 1,746 km | 3h 5m | AK, MH |