Sultan Ismail offers nonstop service to 19 destinations, served by 6 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Kuala Lumpur | KUL | Malaysia | 249 km | 1h 0m | AK, MH, OD, FY |
| Kuala Lumpur | SZB | Malaysia | 286 km | 1h 5m | FY, OD |
| Ipoh | IPH | Malaysia | 432 km | 1h 0m | AK |
| Kota Bharu | KBR | Malaysia | 524 km | 1h 5m | AK |
| Penang | PEN | Malaysia | 553 km | 1h 10m | AK, OD |
| Alor Setar | AOR | Malaysia | 620 km | 1h 15m | AK |
| Langkawi | LGK | Malaysia | 679 km | 1h 15m | AK |
| Kuching | KCH | Malaysia | 742 km | 1h 25m | AK |
| Jakarta | CGK | Indonesia | 920 km | 1h 45m | QZ |
| Sibu | SBW | Malaysia | 928 km | 1h 35m | AK |
| Ho Chi Minh City | SGN | Viet Nam | 1,067 km | 1h 55m | AK |
| Miri | MYY | Malaysia | 1,185 km | 2h 0m | AK |
| Bangkok | DMK | Thailand | 1,398 km | 2h 20m | FD |
| Surabaya | SUB | Indonesia | 1,421 km | 2h 25m | QZ |
| Kota Kinabalu | BKI | Malaysia | 1,454 km | 2h 20m | AK |
| Tawau | TWU | Malaysia | 1,633 km | 2h 35m | AK |
| Kunming | KMG | China | 2,597 km | 3h 55m | OD, AK |
| Guangzhou | CAN | China | 2,621 km | 4h 0m | AK |
| Madinah | MED | Saudi Arabia | 7,313 km | 9h 45m | MH |