Nuuk offers nonstop service to 15 destinations, served by 4 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Maniitsoq | JSU | Greenland | 148 km | 0h 35m | GL |
| Paamiut | JFR | Greenland | 262 km | 0h 55m | GL |
| Kangerlussuaq | SFJ | Greenland | 318 km | 1h 0m | GL |
| Sisimiut | JHS | Greenland | 322 km | 1h 0m | GL |
| Narsarsuaq | UAK | Greenland | 466 km | 1h 20m | GL |
| Qaqortoq | JJU | Greenland | 484 km | 1h 25m | GL |
| Aasiaat | JEG | Greenland | 505 km | 1h 25m | GL |
| Ilulissat | JAV | Greenland | 565 km | 1h 30m | GL |
| Kulusuk | KUS | Greenland | 707 km | 1h 50m | GL |
| Iqaluit | YFB | Canada | 822 km | 2h 25m | GL |
| Reykjavik | KEF | Iceland | 1,407 km | 2h 25m | GL, FI |
| New York | EWR | USA | 2,991 km | 4h 35m | UA |
| Aalborg | AAL | Denmark | 3,319 km | 4h 50m | GL |
| Billund | BLL | Denmark | 3,381 km | 4h 30m | GL |
| Copenhagen | CPH | Denmark | 3,554 km | 4h 40m | GL, SK |