Columbia Rgnl offers nonstop service to 18 destinations, served by 3 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Chicago | ORD | USA | 507 km | 1h 43m | AA, UA |
| Dallas | DFW | USA | 787 km | 1h 59m | AA |
| Houston | IAH | USA | 1,020 km | 2h 3m | AA |
| Fort Walton Beach | VPS | USA | 1,058 km | 1h 54m | G4 |
| Austin | AUS | USA | 1,077 km | 1h 45m | AA |
| Charlotte | CLT | USA | 1,079 km | 2h 13m | AA |
| Denver | DEN | USA | 1,079 km | 2h 34m | UA |
| Saint Petersburg | PIE | USA | 1,497 km | 2h 29m | G4 |
| Orlando | SFB | USA | 1,505 km | 2h 28m | G4 |