Columbia Metropolitan offers nonstop service to 13 destinations, served by 4 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Charlotte | CLT | USA | 143 km | 1h 17m | AA |
| Atlanta | ATL | USA | 309 km | 1h 12m | DL |
| Birmingham | BHM | USA | 523 km | 1h 25m | AA |
| Orlando | SFB | USA | 572 km | 1h 31m | G4 |
| Dulles | IAD | USA | 646 km | 1h 38m | UA |
| Washington | DCA | USA | 656 km | 1h 39m | AA |
| Philadelphia | PHL | USA | 841 km | 1h 56m | AA |
| Fort Lauderdale | FLL | USA | 877 km | 1h 51m | G4 |
| Miami | MIA | USA | 906 km | 2h 1m | AA |
| New York | EWR | USA | 968 km | 2h 11m | UA |
| New York | LGA | USA | 993 km | 1h 59m | DL, AA |
| Chicago | ORD | USA | 1,072 km | 2h 24m | UA, AA |
| Dallas | DFW | USA | 1,483 km | 3h 2m | AA |