Birmingham International offers nonstop service to 26 destinations, served by 5 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Atlanta | ATL | USA | 214 km | 1h 9m | DL |
| Nashville | BNA | USA | 285 km | 1h 5m | WN |
| Tallahassee | TLH | USA | 418 km | 1h 20m | AA |
| Columbia | CAE | USA | 523 km | 1h 30m | AA |
| Lexington | LEX | USA | 533 km | 1h 40m | AA |
| Charlotte | CLT | USA | 565 km | 1h 40m | AA |
| Tampa | TPA | USA | 738 km | 1h 25m | WN |
| Orlando | MCO | USA | 770 km | 1h 35m | WN |
| Raleigh/Durham | RDU | USA | 772 km | 1h 35m | MX |
| Houston | IAH | USA | 904 km | 2h 4m | UA |
| Houston | HOU | USA | 917 km | 1h 55m | WN |
| Chicago | MDW | USA | 917 km | 1h 50m | WN |
| Chicago | ORD | USA | 939 km | 2h 22m | AA, UA |
| Dallas | DAL | USA | 944 km | 1h 55m | WN |
| Dallas | DFW | USA | 960 km | 2h 15m | AA |
| College Station | CLL | USA | 965 km | 2h 40m | AA |
| Detroit | DTW | USA | 1,004 km | 2h 3m | DL |
| Fort Lauderdale | FLL | USA | 1,046 km | 1h 55m | MX |
| Washington | DCA | USA | 1,051 km | 2h 10m | AA |
| Miami | MIA | USA | 1,064 km | 1h 59m | AA |
| Baltimore | BWI | USA | 1,097 km | 2h 0m | WN |
| Philadelphia | PHL | USA | 1,242 km | 2h 21m | AA |
| New York | LGA | USA | 1,393 km | 2h 30m | DL |
| Denver | DEN | USA | 1,742 km | 3h 0m | UA, WN |
| Phoenix | PHX | USA | 2,340 km | 3h 50m | WN |
| Las Vegas | LAS | USA | 2,603 km | 4h 10m | WN |