Nantucket Mem offers nonstop service to 30 destinations, served by 6 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Martha's Vineyard | MVY | USA | 48 km | 0h 25m | 9K |
| Hyannis | HYA | USA | 49 km | 0h 30m | 9K |
| New Bedford | EWB | USA | 88 km | 0h 38m | 9K |
| Norwood | OWD | USA | 139 km | 0h 55m | 9K |
| Boston | BOS | USA | 146 km | 0h 55m | 9K, AA, B6 |
| Bedford/Hanscom | BED | USA | 169 km | 0h 45m | TJ |
| Westchester County | HPN | USA | 306 km | 1h 5m | B6, TJ |
| New York | JFK | USA | 321 km | 1h 6m | B6, DL |
| New York | LGA | USA | 325 km | 1h 23m | AA, B6, DL |
| Teterboro | TEB | USA | 339 km | 1h 9m | TJ |
| New York | EWR | USA | 352 km | 1h 44m | UA |
| Philadelphia | PHL | USA | 464 km | 1h 49m | AA |
| Washington | DCA | USA | 652 km | 1h 47m | AA, B6 |
| Charlotte | CLT | USA | 1,162 km | 2h 24m | AA |
| Chicago | ORD | USA | 1,486 km | 2h 58m | AA |