Playa De Oro International offers nonstop service to 14 destinations, served by 6 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Mexico City | MEX | Mexico | 577 km | 1h 36m | AM |
| Mexico City | NLU | Mexico | 586 km | 1h 33m | VB |
| Houston | IAH | USA | 1,519 km | 2h 37m | UA |
| Dallas | DFW | USA | 1,698 km | 2h 40m | AA |
| Phoenix | PHX | USA | 1,747 km | 2h 58m | AA |
| Los Angeles | LAX | USA | 2,138 km | 3h 38m | AS |
| Calgary | YYC | Canada | 3,645 km | 5h 20m | WS |