Playa De Oro International offers nonstop service to 6 destinations, served by 5 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Mexico City | MEX | Mexico | 577 km | 1h 35m | AM |
| Houston | IAH | USA | 1,519 km | 2h 36m | UA |
| Dallas | DFW | USA | 1,698 km | 2h 51m | AA |
| Phoenix | PHX | USA | 1,747 km | 2h 55m | AA |
| Los Angeles | LAX | USA | 2,138 km | 3h 40m | AS |
| Calgary | YYC | Canada | 3,645 km | 5h 14m | WS |