La Calera Airport offers nonstop service to 14 destinations, served by 3 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Guadalajara | GDL | Mexico | 271 km | 1h 3m | Y4 |
| Mexico City | MEX | Mexico | 536 km | 1h 27m | AM |
| Dallas | DFW | USA | 1,239 km | 2h 21m | AA |
| Tijuana | TIJ | Mexico | 1,765 km | 2h 47m | Y4 |
| Los Angeles | LAX | USA | 1,963 km | 3h 19m | Y4 |
| San Jose | SJC | USA | 2,442 km | 3h 50m | Y4 |
| Chicago | MDW | USA | 2,514 km | 3h 41m | Y4 |