Xuzhou Guanyin Airport offers nonstop service to 30 destinations, served by 15 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Nanchang | KHN | China | 596 km | 1h 25m | RY |
| Zhoushan | HSN | China | 643 km | 1h 30m | G5 |
| Dalian | DLC | China | 650 km | 1h 30m | GJ, G5 |
| Yichang | YIH | China | 691 km | 1h 50m | GS, TV |
| Changsha | CSX | China | 770 km | 1h 40m | GX |
| Dayong | DYG | China | 869 km | 2h 0m | GT |
| Hohhot | HET | China | 909 km | 2h 10m | HU |
| Dongsheng | DSN | China | 913 km | 2h 0m | MU, KN |
| Fuzhou | FOC | China | 923 km | 1h 45m | GJ |
| Shenyang | SHE | China | 989 km | 2h 5m | 3U, GJ, SC |
| Jinjiang | JJN | China | 1,030 km | 2h 0m | GJ, G5 |
| Xiamen | XMN | China | 1,055 km | 2h 3m | SC |
| Yinchuan | INC | China | 1,109 km | 2h 30m | GJ |
| Chongqing | CKG | China | 1,138 km | 2h 25m | G5 |
| Jieyang | SWA | China | 1,168 km | 2h 20m | CZ |
| Guilin | KWL | China | 1,219 km | 2h 25m | GT |
| Guangzhou | CAN | China | 1,252 km | 2h 33m | CZ, GJ |
| Chengdu | TFU | China | 1,303 km | 2h 35m | 3U, GJ |
| Changchun | CGQ | China | 1,307 km | 2h 20m | GJ |
| Shenzhen | SZX | China | 1,317 km | 2h 35m | HU, GJ |
| Guiyang | KWE | China | 1,326 km | 2h 40m | 3U, 8L |
| Yibin | YBP | China | 1,365 km | 3h 3m | TV |
| Zhuhai | ZUH | China | 1,396 km | 2h 45m | GJ |
| Zhuhai | ZUH | China | 1,396 km | 2h 45m | GJ |
| Harbin | HRB | China | 1,481 km | 2h 35m | 3U, GJ, PN |
| Nanning | NNG | China | 1,565 km | 2h 40m | GX |
| Haikou | HAK | China | 1,714 km | 2h 50m | GX, GJ |
| Kunming | KMG | China | 1,726 km | 3h 5m | 3U, 8L, GJ |
| Sanya | SYX | China | 1,923 km | 3h 20m | PN |
| Jinghong | JHG | China | 2,120 km | 3h 58m | GJ, GT |