Xuzhou Guanyin Airport offers nonstop service to 62 destinations, served by 13 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Nanchang | KHN | China | 596 km | 1h 25m | RY |
| Zhoushan | HSN | China | 643 km | 1h 30m | G5 |
| Dalian | DLC | China | 650 km | 1h 35m | G5, GJ |
| Yichang | YIH | China | 691 km | 1h 50m | GS, TV |
| Changsha | CSX | China | 770 km | 2h 0m | GX |
| Yan'an | ENY | China | 783 km | 2h 0m | RY |
| Hohhot | HET | China | 909 km | 2h 5m | HU |
| Dongsheng | DSN | China | 913 km | 2h 8m | MU |
| Ganzhou | KOW | China | 948 km | 1h 50m | G5 |
| Shenyang | SHE | China | 989 km | 2h 10m | 3U, GJ, SC |
| Jinjiang | JJN | China | 1,030 km | 2h 5m | G5, GJ |
| Xiamen | XMN | China | 1,055 km | 2h 0m | GS, SC |
| Yinchuan | INC | China | 1,109 km | 2h 25m | GJ |
| Chongqing | CKG | China | 1,138 km | 2h 15m | G5 |
| Jieyang | SWA | China | 1,168 km | 2h 20m | CZ |
| Guilin | KWL | China | 1,219 km | 2h 20m | GT |
| Guangzhou | CAN | China | 1,252 km | 2h 30m | CZ, GJ |
| Chengdu | TFU | China | 1,303 km | 2h 25m | 3U, GJ |
| Changchun | CGQ | China | 1,307 km | 2h 20m | GJ |
| Shenzhen | SZX | China | 1,317 km | 2h 40m | GJ, HU |
| Guiyang | KWE | China | 1,326 km | 2h 40m | 3U, 8L |
| Chengdu | CTU | China | 1,335 km | 2h 15m | 3U |
| Yibin | YBP | China | 1,365 km | 2h 55m | TV |
| Zhuhai | ZUH | China | 1,396 km | 2h 43m | GJ |
| Xining | XNN | China | 1,435 km | 2h 45m | GJ |
| Harbin | HRB | China | 1,481 km | 2h 35m | 3U, GJ |
| Nanning | NNG | China | 1,565 km | 2h 43m | GX |
| Haikou | HAK | China | 1,714 km | 2h 53m | GJ, GX |
| Kunming | KMG | China | 1,726 km | 3h 0m | 3U, 8L, GJ |
| Jinghong | JHG | China | 2,120 km | 3h 10m | GJ |
| Urumqi | URC | China | 2,806 km | 4h 45m | GS |