Van Nuys offers nonstop service to 9 destinations, served by 1 airline.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Thermal | TRM | USA | 224 km | 0h 45m | 5E |
| Las Vegas | LAS | USA | 368 km | 1h 5m | 5E |
| Napa | APC | USA | 559 km | 1h 20m | 5E |
| Sun Valley | SUN | USA | 1,093 km | 2h 0m | 5E |
| Aspen | ASE | USA | 1,176 km | 2h 10m | 5E |
| San Jose Cabo | SJD | Mexico | 1,493 km | 2h 30m | 5E |
| Teterboro | TEB | USA | 3,952 km | 4h 40m | 5E |
| Kahului | OGG | USA | 3,999 km | 5h 45m | 5E |
| Holy Cross | HCR | USA | 4,239 km | 3h 50m | 5E |