St. Lucia offers nonstop service to 26 destinations, served by 7 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| St. George's | GND | Grenada | 211 km | 0h 55m | BA |
| Tobago | TAB | Trinidad and Tobago | 286 km | 1h 5m | BA |
| Georgetown | GEO | Guyana | 852 km | 1h 40m | BA |
| Miami | MIA | USA | 2,420 km | 3h 59m | AA |
| Charlotte | CLT | USA | 3,111 km | 5h 4m | AA |
| Philadelphia | PHL | USA | 3,216 km | 5h 18m | AA |
| New York | JFK | USA | 3,233 km | 5h 5m | AA, B6 |
| Atlanta | ATL | USA | 3,239 km | 5h 5m | DL |
| New York | EWR | USA | 3,252 km | 5h 20m | UA |
| Boston | BOS | USA | 3,318 km | 5h 15m | B6 |
| Toronto | YYZ | Canada | 3,766 km | 5h 50m | AC, WS |
| Chicago | ORD | USA | 4,068 km | 6h 23m | UA |
| London | LGW | United Kingdom | 6,802 km | 8h 15m | BA |