La Palma offers nonstop service to 21 destinations, served by 14 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Tenerife | TFS | Spain | 132 km | 0h 40m | NT, WK |
| Tenerife | TFN | Spain | 138 km | 0h 30m | NT, PM |
| Las Palmas | LPA | Spain | 244 km | 0h 50m | NT, PM |
| Puerto del Rosario | FUE | Spain | 380 km | 0h 45m | NT, LG |
| Lanzarote | ACE | Spain | 406 km | 1h 10m | NT |
| Madrid | MAD | Spain | 1,846 km | 2h 45m | IB |
| Barcelona | BCN | Spain | 2,283 km | 3h 25m | VY |
| Nantes | NTE | France | 2,488 km | 3h 40m | V7 |
| London | LGW | United Kingdom | 2,901 km | 4h 35m | LS |
| London | STN | United Kingdom | 2,985 km | 4h 35m | LS |
| Manchester | MAN | United Kingdom | 3,025 km | 4h 35m | LS |
| Basel, Switzerland/Mulhouse | BSL | France | 3,032 km | 4h 10m | U2 |
| Zurich | ZRH | Switzerland | 3,087 km | 4h 20m | WK |
| Luxembourg | LUX | Luxembourg | 3,092 km | 4h 35m | LG |
| Stuttgart | STR | Germany | 3,202 km | 4h 30m | EW |
| Amsterdam | AMS | Netherlands | 3,221 km | 4h 33m | HV |
| Dusseldorf | DUS | Germany | 3,241 km | 4h 30m | DE, EW |
| Frankfurt | FRA | Germany | 3,254 km | 4h 30m | DE, 4Y |
| Munich | MUC | Germany | 3,345 km | 4h 30m | DE, 4Y |
| Hamburg | HAM | Germany | 3,579 km | 4h 55m | EW, DI |
| Berlin | BER | Germany | 3,684 km | 5h 10m | U2 |