Southampton offers nonstop service to 17 destinations, served by 5 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Alderney | ACI | Guernsey | 151 km | 0h 55m | GR |
| Guernsey | GCI | Guernsey | 190 km | 0h 45m | GR |
| Jersey | JER | Jersey | 203 km | 0h 50m | LM |
| Manchester | MAN | United Kingdom | 275 km | 0h 55m | LM |
| Paris | ORY | France | 364 km | 1h 0m | U2 |
| Dublin | DUB | Ireland | 432 km | 1h 38m | EI |
| Amsterdam | AMS | Netherlands | 450 km | 1h 10m | KL, U2 |
| Newcastle | NCL | United Kingdom | 455 km | 1h 10m | LM |
| Belfast | BHD | United Kingdom | 508 km | 1h 35m | EI |
| Belfast | BFS | United Kingdom | 526 km | 1h 15m | U2 |
| Edinburgh | EDI | United Kingdom | 571 km | 1h 45m | LM |
| Glasgow | GLA | United Kingdom | 583 km | 1h 20m | U2 |
| Geneva | GVA | Switzerland | 760 km | 1h 35m | U2 |
| Barcelona | BCN | Spain | 1,104 km | 1h 55m | U2 |
| Palma de Mallorca | PMI | Spain | 1,306 km | 2h 13m | U2 |
| Alicante | ALC | Spain | 1,408 km | 2h 15m | U2 |
| Faro | FAO | Portugal | 1,634 km | 2h 40m | U2 |