Santo International Airport offers nonstop service to 11 destinations, served by 2 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Walaha | WLH | Vanuatu | 51 km | 0h 25m | NF |
| Norsup | NUS | Vanuatu | 64 km | 0h 25m | NF |
| Longana | LOD | Vanuatu | 82 km | 0h 30m | NF |
| Arongbwaratu | SSR | Vanuatu | 100 km | 0h 30m | NF |
| Lonorore | LNE | Vanuatu | 108 km | 0h 35m | NF |
| Maewo | MWF | Vanuatu | 108 km | 0h 35m | NF |
| Gaua | ZGU | Vanuatu | 147 km | 0h 45m | NF |
| Sola | SLH | Vanuatu | 186 km | 0h 50m | NF |
| Mota Lava Island | MTV | Vanuatu | 209 km | 1h 0m | NF |
| Port Vila | VLI | Vanuatu | 269 km | 0h 50m | NF |
| Brisbane | BNE | Australia | 1,965 km | 2h 50m | IE |