Samos offers nonstop service to 17 destinations, served by 15 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Chios | JKH | Greece | 99 km | 0h 40m | GQ |
| Mytilene | MJT | Greece | 153 km | 1h 0m | OR |
| Rhodes | RHO | Greece | 177 km | 0h 45m | GQ |
| Athens | ATH | Greece | 262 km | 1h 0m | GQ, A3 |
| Thessaloniki | SKG | Greece | 463 km | 1h 20m | GQ, OA |
| Vienna | VIE | Austria | 1,431 km | 2h 30m | OS |
| Munich | MUC | Germany | 1,703 km | 2h 45m | 4Y |
| Prague | PRG | Czech Republic | 1,708 km | 2h 45m | QS |
| Milan | MXP | Italy | 1,747 km | 3h 0m | NO |
| Zurich | ZRH | Switzerland | 1,848 km | 2h 55m | WK |
| Frankfurt | FRA | Germany | 2,004 km | 3h 10m | DE |
| Dusseldorf | DUS | Germany | 2,188 km | 3h 15m | EW, DE |
| Brussels | BRU | Belgium | 2,298 km | 3h 40m | TB, SN |
| Amsterdam | AMS | Netherlands | 2,367 km | 3h 40m | HV, OR |
| London | STN | United Kingdom | 2,609 km | 4h 5m | LS |
| Birmingham | BHX | United Kingdom | 2,759 km | 4h 10m | LS |
| Manchester | MAN | United Kingdom | 2,835 km | 4h 15m | LS |