Samarkand offers nonstop service to 24 destinations, served by 18 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Tashkent | TAS | Uzbekistan | 260 km | 0h 50m | HY, C6, UH |
| Almaty | ALA | Kazakhstan | 930 km | 1h 50m | FS |
| Astana | NQZ | Kazakhstan | 1,306 km | 2h 40m | IQ |
| Baku | GYD | Azerbaijan | 1,445 km | 2h 20m | J2 |
| Urumqi | URC | China | 1,760 km | 2h 30m | CZ |
| Ufa | UFA | Russia | 1,850 km | 2h 45m | A4 |
| Dubai | DXB | United Arab Emirates | 1,934 km | 3h 25m | FZ |
| Yekaterinburg | SVX | Russia | 1,949 km | 3h 5m | U6 |
| Mineralnye Vody | MRV | Russia | 2,036 km | 3h 10m | A4 |
| Novosibirsk | OVB | Russia | 2,063 km | 3h 10m | S7 |
| Kazan | KZN | Russia | 2,199 km | 3h 30m | HY |
| Adler/Sochi | AER | Russia | 2,283 km | 3h 50m | A4, U6, C6 |
| Krasnodar | KRR | Russia | 2,356 km | 4h 5m | A4 |
| Krasnojarsk | KJA | Russia | 2,614 km | 3h 25m | U6 |
| Zhukovsky | ZIA | Russia | 2,759 km | 4h 15m | U6 |
| Moscow | DME | Russia | 2,766 km | 4h 20m | U6, HH, C6 |
| Moscow | VKO | Russia | 2,810 km | 4h 15m | UT, HY, DP |
| Moscow | SVO | Russia | 2,821 km | 4h 20m | SU |
| Tel Aviv-Yafo | TLV | Israel | 3,006 km | 5h 30m | HH, C6, HY |
| Istanbul | IST | Turkiye | 3,221 km | 5h 15m | HY, TK, C6 |
| Saint Petersburg | LED | Russia | 3,389 km | 5h 5m | HY, SU, HH, UT, C6 |
| Izmir | ADB | Turkiye | 3,426 km | 5h 25m | XQ |
| Xian | XIY | China | 3,726 km | 4h 50m | GJ |
| Vladivostok | VVO | Russia | 5,311 km | 7h 10m | C6 |