Santiago offers nonstop service to 30 destinations, served by 9 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Bilbao | BIO | Spain | 450 km | 1h 10m | IB, VY |
| Madrid | MAD | Spain | 484 km | 1h 15m | IB |
| Sevilla | SVQ | Spain | 644 km | 1h 25m | FR, VY |
| Jerez De La Frontera | XRY | Spain | 711 km | 1h 30m | VY |
| Valencia | VLC | Spain | 765 km | 1h 30m | FR |
| Malaga | AGP | Spain | 768 km | 1h 35m | VY |
| Alicante | ALC | Spain | 838 km | 1h 35m | FR |
| Barcelona | BCN | Spain | 885 km | 1h 40m | FR, VY |
| Ibiza | IBZ | Spain | 936 km | 1h 44m | VY, FR |
| Melilla | MLN | Spain | 968 km | 2h 50m | IB |
| Cork | ORK | Ireland | 995 km | 1h 55m | EI |
| Palma de Mallorca | PMI | Spain | 1,004 km | 1h 50m | VY |
| Paris | ORY | France | 1,057 km | 2h 0m | VY |
| London | LGW | United Kingdom | 1,109 km | 2h 10m | VY |
| London | LHR | United Kingdom | 1,126 km | 2h 8m | VY |
| Dublin | DUB | Ireland | 1,181 km | 2h 5m | EI, FR |
| London | STN | United Kingdom | 1,193 km | 2h 10m | FR |
| Geneva | GVA | Switzerland | 1,209 km | 2h 5m | U2 |
| Marrakech | RAK | Morocco | 1,253 km | 2h 10m | VY |
| Brussels | CRL | Belgium | 1,291 km | 2h 10m | FR |
| Basel, Switzerland/Mulhouse | BSL | France | 1,353 km | 2h 10m | U2 |
| Zurich | ZRH | Switzerland | 1,423 km | 2h 20m | VY, WK |
| Amsterdam | AMS | Netherlands | 1,436 km | 2h 25m | VY, KL |
| Frankfurt | FRA | Germany | 1,522 km | 2h 25m | LH |
| Lanzarote | ACE | Spain | 1,615 km | 2h 40m | FR, VY |
| Puerto del Rosario | FUE | Spain | 1,676 km | 2h 45m | VY |
| Tenerife | TFN | Spain | 1,750 km | 2h 45m | VY |
| Las Palmas | LPA | Spain | 1,775 km | 2h 50m | VY |
| Tenerife | TFS | Spain | 1,804 km | 2h 50m | FR |
| New York | EWR | USA | 5,328 km | 7h 55m | UA |