Rapid City Regional Airport offers nonstop service to 12 destinations, served by 5 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Denver | DEN | USA | 483 km | 1h 33m | UA |
| Minneapolis | MSP | USA | 789 km | 1h 37m | DL, SY |
| Chicago | ORD | USA | 1,254 km | 2h 24m | AA, UA |
| Dallas | DFW | USA | 1,342 km | 2h 27m | AA |
| Las Vegas | LAS | USA | 1,355 km | 2h 24m | G4 |
| Mesa | AZA | USA | 1,404 km | 2h 23m | G4 |
| Phoenix | PHX | USA | 1,408 km | 2h 26m | AA |
| Detroit | DTW | USA | 1,612 km | 2h 30m | DL |
| Houston | IAH | USA | 1,702 km | 2h 55m | UA |
| Atlanta | ATL | USA | 1,978 km | 3h 2m | DL |
| Charlotte | CLT | USA | 2,127 km | 3h 35m | AA |
| Orlando | SFB | USA | 2,573 km | 3h 41m | G4 |