Sultan Syarif Kasim Ii offers nonstop service to 22 destinations, served by 10 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Malacca | MKZ | Malaysia | 218 km | 1h 10m | IW |
| Kuala Lumpur | KUL | Malaysia | 253 km | 0h 55m | AK, JT, MH, OD |
| Singapore | SIN | Singapore | 299 km | 1h 10m | TR |
| Batam | BTH | Indonesia | 305 km | 0h 55m | JT, QG |
| Gunungsitoli | GNS | Indonesia | 447 km | 1h 30m | IW |
| Kuala Namu | KNO | Indonesia | 452 km | 1h 10m | JT |
| Jakarta | CGK | Indonesia | 931 km | 1h 45m | GA, ID, IP, JT, QG |
| Jakarta | HLP | Indonesia | 959 km | 1h 50m | QG |
| Bandung | BDO | Indonesia | 1,062 km | 2h 0m | |
| Yogyakarta | YIA | Indonesia | 1,330 km | 2h 10m | JT |
| Surabaya | SUB | Indonesia | 1,529 km | 2h 40m | JT |