Prestwick offers nonstop service to 22 destinations, served by 1 airline.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Turin | TRN | Italy | 1,436 km | 2h 30m | FR |
| Barcelona | BCN | Spain | 1,653 km | 2h 35m | FR |
| Pisa | PSA | Italy | 1,696 km | 2h 35m | FR |
| Palma de Mallorca | PMI | Spain | 1,856 km | 2h 50m | FR |
| Alicante | ALC | Spain | 1,938 km | 3h 0m | FR |
| Corvera | RMU | Spain | 1,985 km | 3h 5m | FR |
| Faro | FAO | Portugal | 2,070 km | 3h 5m | FR |
| Malaga | AGP | Spain | 2,093 km | 3h 15m | FR |
| Lanzarote | ACE | Spain | 3,036 km | 4h 25m | FR |
| Las Palmas | LPA | Spain | 3,182 km | 4h 35m | FR |
| Tenerife | TFS | Spain | 3,198 km | 4h 40m | FR |