Sant Egidio Airport offers nonstop service to 28 destinations, served by 6 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Aosta | AOT | Italy | 504 km | 1h 0m | BN |
| Cagliari | CAG | Italy | 515 km | 1h 15m | FR |
| Brindisi | BDS | Italy | 525 km | 1h 10m | FR |
| Palermo | PMO | Italy | 547 km | 1h 15m | FR |
| Tirana | TIA | Albania | 622 km | 1h 25m | W4 |
| Catania | CTA | Italy | 661 km | 1h 25m | FR |
| Malta | MLA | Malta | 822 km | 1h 30m | FR |
| Barcelona | BCN | Spain | 884 km | 1h 50m | FR |
| Krakow | KRK | Poland | 954 km | 1h 50m | FR |
| Brussels | CRL | Belgium | 1,022 km | 1h 55m | FR |
| Bucharest | OTP | Romania | 1,101 km | 2h 0m | FR |
| Rotterdam | RTM | Netherlands | 1,155 km | 2h 5m | HV |
| London | STN | United Kingdom | 1,340 km | 2h 25m | FR, RK |
| London | LHR | United Kingdom | 1,348 km | 2h 18m | BA |