Ponta Delgada offers nonstop service to 60 destinations, served by 15 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Santa Maria (Azores) | SMA | Portugal | 101 km | 0h 30m | SP |
| Terceira | TER | Portugal | 165 km | 0h 40m | S4, SP |
| Sao Jorge Island | SJZ | Portugal | 239 km | 0h 55m | SP |
| Graciosa Island (Azores) | GRW | Portugal | 252 km | 0h 55m | SP |
| Pico Island (Azores) | PIX | Portugal | 256 km | 0h 55m | SP |
| Horta (Azores) | HOR | Portugal | 278 km | 0h 55m | SP |
| Flores Island (Azores) | FLW | Portugal | 511 km | 1h 25m | SP |
| Corvo Island (Azores) | CVU | Portugal | 517 km | 1h 35m | SP |
| Funchal | FNC | Portugal | 985 km | 1h 40m | S4 |
| Tenerife | TFN | Spain | 1,345 km | 2h 15m | NT |
| Lisbon | LIS | Portugal | 1,452 km | 2h 20m | S4, TP |
| Las Palmas | LPA | Spain | 1,452 km | 2h 10m | NT |
| Porto | OPO | Portugal | 1,512 km | 2h 20m | S4 |
| Faro | FAO | Portugal | 1,569 km | 2h 25m | S4 |
| Madrid | MAD | Spain | 1,932 km | 3h 0m | IB |
| Barcelona | BCN | Spain | 2,409 km | 3h 30m | S4 |
| London | LHR | United Kingdom | 2,496 km | 3h 53m | BA |
| Praia | RAI | Cape Verde | 2,535 km | 3h 43m | S4 |
| Paris | CDG | France | 2,588 km | 3h 40m | S4 |
| Amsterdam | AMS | Netherlands | 2,861 km | 4h 25m | HV |
| Dusseldorf | DUS | Germany | 2,952 km | 4h 25m | EW |
| Zurich | ZRH | Switzerland | 2,981 km | 4h 35m | WK |
| Frankfurt | FRA | Germany | 3,038 km | 4h 20m | LH, S4 |
| Prague | PRG | Czech Republic | 3,439 km | 4h 35m | QS |
| Vienna | VIE | Austria | 3,585 km | 5h 3m | OS |
| Boston | BOS | USA | 3,855 km | 5h 45m | S4 |
| Montreal | YUL | Canada | 4,034 km | 5h 55m | S4 |
| New York | JFK | USA | 4,115 km | 6h 5m | S4 |
| New York | EWR | USA | 4,146 km | 6h 15m | UA |
| Toronto | YYZ | Canada | 4,522 km | 6h 38m | AC, S4, WS |