Manchester offers nonstop service to 28 destinations, served by 4 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Philadelphia | PHL | USA | 464 km | 1h 39m | AA |
| Baltimore | BWI | USA | 605 km | 1h 40m | WN |
| Washington | DCA | USA | 653 km | 1h 57m | AA |
| Dulles | IAD | USA | 671 km | 1h 57m | UA |
| Raleigh/Durham | RDU | USA | 1,006 km | 2h 18m | MX |
| Charlotte | CLT | USA | 1,184 km | 2h 35m | AA |
| Myrtle Beach | MYR | USA | 1,216 km | 2h 18m | MX |
| Charleston | CHS | USA | 1,345 km | 2h 44m | MX |
| Chicago | MDW | USA | 1,346 km | 2h 35m | WN |
| Chicago | ORD | USA | 1,356 km | 2h 56m | AA |
| Nashville | BNA | USA | 1,507 km | 2h 50m | WN |
| Orlando | MCO | USA | 1,836 km | 3h 20m | WN |
| Tampa | TPA | USA | 1,936 km | 3h 25m | WN |
| Fort Myers | RSW | USA | 2,046 km | 3h 45m | MX, WN |