Khudzhand Airport offers nonstop service to 14 destinations, served by 6 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Kashi | KHG | China | 545 km | 1h 25m | EU |
| Urumqi | URC | China | 1,523 km | 2h 40m | SZ |
| Ufa | UFA | Russia | 1,897 km | 3h 5m | N4 |
| Novosibirsk | OVB | Russia | 1,904 km | 2h 55m | S7 |
| Tyumen | TJM | Russia | 1,912 km | 3h 0m | UT, N4 |
| Yekaterinburg | SVX | Russia | 1,948 km | 2h 55m | U6 |
| Samara | KUF | Russia | 2,085 km | 3h 18m | U6 |
| Mineralnye Vody | MRV | Russia | 2,231 km | 3h 30m | U6 |
| Kazan | KZN | Russia | 2,274 km | 3h 35m | N4 |
| Surgut | SGC | Russia | 2,363 km | 3h 40m | UT, SZ |
| Krasnojarsk | KJA | Russia | 2,430 km | 3h 30m | U6 |
| Zhukovsky | ZIA | Russia | 2,870 km | 4h 25m | U6, SZ |
| Moscow | DME | Russia | 2,879 km | 4h 40m | SZ |
| Saint Petersburg | LED | Russia | 3,483 km | 5h 20m | U6 |