Megas Alexandros International offers nonstop service to 9 destinations, served by 5 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Athens | ATH | Greece | 335 km | 1h 15m | A3 |
| Vienna | VIE | Austria | 1,024 km | 1h 50m | OS |
| Munich | MUC | Germany | 1,308 km | 2h 15m | DE |
| Nuremberg | NUE | Germany | 1,424 km | 2h 15m | DI |
| Stuttgart | STR | Germany | 1,490 km | 2h 30m | EW |
| Berlin | BER | Germany | 1,527 km | 2h 35m | EW |
| Frankfurt | FRA | Germany | 1,608 km | 2h 50m | DE |
| Cologne | CGN | Germany | 1,744 km | 2h 50m | EW |
| Dusseldorf | DUS | Germany | 1,789 km | 2h 50m | EW |