Ketchikan International offers nonstop service to 12 destinations, served by 4 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Metlakatla | MTM | USA | 26 km | 0h 12m | K3 |
| Kasaan | KXA | USA | 48 km | 0h 25m | K3 |
| Meyers Chuck | WMK | USA | 55 km | 0h 25m | K3 |
| Thorne Bay | KTB | USA | 63 km | 0h 23m | K3 |
| Klawock | KLW | USA | 90 km | 0h 30m | I4, X4 |
| Coffman Cove | KCC | USA | 102 km | 0h 45m | K3 |
| Wrangell | WRG | USA | 132 km | 0h 41m | AS |
| Edna Bay | EDA | USA | 139 km | 0h 50m | K3 |
| Point Baker | KPB | USA | 163 km | 1h 0m | K3 |
| Sitka | SIT | USA | 294 km | 0h 56m | AS |
| Juneau | JNU | USA | 377 km | 1h 0m | AS |
| Seattle | SEA | USA | 1,095 km | 2h 1m | AS |