Skiathos Airport offers nonstop service to 31 destinations, served by 15 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Athens | ATH | Greece | 143 km | 0h 40m | GQ, OA |
| Preveza | PVK | Greece | 238 km | 0h 50m | WK |
| Mytilene | MJT | Greece | 268 km | 0h 45m | HV |
| Sofia | SOF | Bulgaria | 390 km | 1h 5m | FR |
| Bari | BRI | Italy | 613 km | 1h 25m | FR |
| Bucharest | OTP | Romania | 635 km | 1h 25m | FR |
| Naples | NAP | Italy | 808 km | 1h 40m | V7, U2 |
| Budapest | BUD | Hungary | 979 km | 1h 50m | FR |
| Rome | FCO | Italy | 996 km | 2h 0m | FR, W4 |
| Larnaca | LCA | Cyprus | 1,017 km | 1h 50m | CY |
| Bratislava | BTS | Slovakia | 1,119 km | 2h 5m | FR |
| Vienna | VIE | Austria | 1,139 km | 2h 0m | OS |
| Venice | VCE | Italy | 1,155 km | 2h 5m | V7 |
| Pisa | PSA | Italy | 1,202 km | 2h 10m | FR |
| Milan | BGY | Italy | 1,342 km | 2h 20m | FR |
| Munich | MUC | Germany | 1,385 km | 2h 20m | DE, 4Y |
| Milan | MXP | Italy | 1,409 km | 2h 30m | U2, W4 |
| Prague | PRG | Czech Republic | 1,415 km | 2h 25m | FR |
| Basel, Switzerland/Mulhouse | BSL | France | 1,591 km | 2h 45m | U2 |
| Frankfurt | FRA | Germany | 1,686 km | 2h 50m | 4Y |
| Paris | ORY | France | 1,991 km | 3h 20m | TO |
| London | LGW | United Kingdom | 2,271 km | 3h 40m | U2, LS |
| London | LCY | United Kingdom | 2,275 km | 3h 40m | BA |
| London | STN | United Kingdom | 2,283 km | 3h 40m | LS |
| London | LTN | United Kingdom | 2,321 km | 3h 40m | LS |
| Leicestershire | EMA | United Kingdom | 2,428 km | 3h 35m | LS |
| Birmingham | BHX | United Kingdom | 2,433 km | 3h 40m | LS |
| Bristol | BRS | United Kingdom | 2,443 km | 3h 48m | LS, U2 |
| Leeds | LBA | United Kingdom | 2,504 km | 3h 45m | LS |
| Manchester | MAN | United Kingdom | 2,512 km | 3h 50m | LS, U2 |
| Newcastle | NCL | United Kingdom | 2,575 km | 4h 5m | LS |