Mount Isa offers nonstop service to 14 destinations, served by 3 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Cloncurry | CNJ | Australia | 105 km | 0h 35m | QF |
| Julia Creek | JCK | Australia | 230 km | 0h 45m | ZL |
| Boulia | BQL | Australia | 250 km | 0h 50m | ZL |
| Doomadgee | DMD | Australia | 310 km | 1h 0m | ZL |
| Townsville | TSV | Australia | 777 km | 1h 45m | QF |
| Cairns | CNS | Australia | 782 km | 2h 0m | ZL |
| Brisbane | BNE | Australia | 1,571 km | 2h 25m | QF, VA |