Nis offers nonstop service to 16 destinations, served by 5 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Belgrade | BEG | Republic of Serbia | 207 km | 0h 50m | JU |
| Tivat | TIV | Montenegro | 276 km | 0h 50m | JU |
| Kerkyra | CFU | Greece | 445 km | 1h 5m | FR |
| Istanbul | IST | Turkiye | 611 km | 1h 35m | JU |
| Athens | ATH | Greece | 624 km | 1h 50m | JU |
| Ljubljana | LJU | Slovenia | 668 km | 1h 50m | JU |
| Vienna | VIE | Austria | 672 km | 1h 20m | FR |
| Memmingen | FMM | Germany | 1,041 km | 2h 0m | W4 |
| Malta | MLA | Malta | 1,043 km | 1h 55m | FR |
| Zurich | ZRH | Switzerland | 1,135 km | 2h 10m | LX |
| Stuttgart | STR | Germany | 1,145 km | 2h 10m | W6 |
| Mulhouse, France/Basel | MLH | Switzerland | 1,214 km | 2h 13m | W6 |
| Hahn | HHN | Germany | 1,334 km | 2h 15m | JU |
| Cologne | CGN | Germany | 1,394 km | 2h 20m | JU |
| Dortmund | DTM | Germany | 1,403 km | 2h 30m | W6 |
| Stockholm | ARN | Sweden | 1,834 km | 2h 50m | FR |