Hilton Head offers nonstop service to 16 destinations, served by 3 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Charlotte | CLT | USA | 333 km | 1h 21m | AA |
| Atlanta | ATL | USA | 384 km | 1h 16m | DL |
| Washington | DCA | USA | 806 km | 1h 47m | AA |
| Philadelphia | PHL | USA | 980 km | 2h 3m | AA |
| New York | EWR | USA | 1,105 km | 2h 11m | UA |
| New York | LGA | USA | 1,128 km | 2h 7m | DL |
| Chicago | ORD | USA | 1,256 km | 2h 42m | AA, UA |
| Boston | BOS | USA | 1,413 km | 2h 35m | AA |