Hilton Head offers nonstop service to 8 destinations, served by 3 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Charlotte | CLT | USA | 333 km | 1h 22m | AA |
| Atlanta | ATL | USA | 384 km | 1h 18m | DL |
| Washington | DCA | USA | 806 km | 1h 47m | AA |
| Philadelphia | PHL | USA | 980 km | 2h 8m | AA |
| New York | EWR | USA | 1,105 km | 2h 21m | UA |
| New York | LGA | USA | 1,128 km | 2h 10m | DL |
| Chicago | ORD | USA | 1,256 km | 2h 41m | UA, AA |
| Boston | BOS | USA | 1,413 km | 2h 38m | AA |