Piedmont Triad offers nonstop service to 28 destinations, served by 5 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Charlotte | CLT | USA | 133 km | 1h 9m | AA |
| Dulles | IAD | USA | 385 km | 1h 20m | UA |
| Washington | DCA | USA | 398 km | 1h 19m | AA |
| Atlanta | ATL | USA | 494 km | 1h 27m | DL |
| Philadelphia | PHL | USA | 587 km | 1h 34m | AA |
| New York | EWR | USA | 715 km | 1h 49m | UA |
| Detroit | DTW | USA | 738 km | 1h 47m | DL |
| New York | LGA | USA | 740 km | 1h 45m | AA, DL |
| Orlando | MCO | USA | 860 km | 1h 49m | MX |
| Hartford | BDL | USA | 900 km | 1h 45m | MX |
| Saint Petersburg | PIE | USA | 945 km | 1h 49m | G4 |
| Chicago | ORD | USA | 948 km | 2h 25m | AA, UA |
| Miami | MIA | USA | 1,143 km | 2h 11m | AA |
| Dallas | DFW | USA | 1,607 km | 3h 16m | AA |