Genova Sestri offers nonstop service to 26 destinations, served by 14 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Olbia | OLB | Italy | 393 km | 1h 5m | V7, AZ, XZ, W2 |
| Rome | FCO | Italy | 401 km | 1h 5m | AZ, XZ, W2 |
| Alghero | AHO | Italy | 422 km | 1h 20m | XZ, W2 |
| Munich | MUC | Germany | 492 km | 1h 15m | LH, EN |
| Cagliari | CAG | Italy | 573 km | 1h 20m | FR |
| Naples | NAP | Italy | 593 km | 1h 25m | V7, FR |
| Barcelona | BCN | Spain | 652 km | 1h 35m | VY |
| Salerno | QSR | Italy | 652 km | 1h 30m | W2, XZ |
| Paris | ORY | France | 690 km | 1h 35m | V7 |
| Bari | BRI | Italy | 742 km | 1h 30m | FR |
| Brussels | CRL | Belgium | 749 km | 1h 35m | FR |
| Palermo | PMO | Italy | 777 km | 1h 30m | FR |
| Dusseldorf | DUS | Germany | 778 km | 1h 40m | DE |
| Brindisi | BDS | Italy | 854 km | 1h 35m | FR |
| Lamezia-Terme | SUF | Italy | 867 km | 1h 35m | FR |
| Budapest | BUD | Hungary | 873 km | 1h 40m | W6 |
| Amsterdam | AMS | Netherlands | 928 km | 2h 0m | KL |
| Catania | CTA | Italy | 931 km | 1h 45m | FR |
| Tirana | TIA | Albania | 946 km | 1h 45m | W4, FR |
| Krakow | KRK | Poland | 1,038 km | 1h 55m | W6 |
| London | STN | United Kingdom | 1,046 km | 2h 10m | FR, RK |
| Madrid | MAD | Spain | 1,108 km | 2h 15m | V7 |
| Warsaw | WAW | Poland | 1,243 km | 2h 5m | W6 |
| Copenhagen | CPH | Denmark | 1,276 km | 2h 5m | SK |
| Manchester | MAN | United Kingdom | 1,283 km | 2h 20m | FR |
| Bucharest | OTP | Romania | 1,367 km | 2h 15m | FR |