Sioux Falls offers nonstop service to 13 destinations, served by 5 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Minneapolis | MSP | USA | 316 km | 1h 10m | DL |
| Chicago | ORD | USA | 744 km | 1h 54m | AA, UA |
| Denver | DEN | USA | 778 km | 1h 56m | F9, UA |
| Dallas | DFW | USA | 1,186 km | 2h 23m | AA |
| Nashville | BNA | USA | 1,192 km | 2h 0m | G4 |
| Atlanta | ATL | USA | 1,534 km | 2h 40m | DL |
| Mesa | AZA | USA | 1,725 km | 2h 52m | G4 |
| Phoenix | PHX | USA | 1,738 km | 3h 4m | AA |
| Las Vegas | LAS | USA | 1,776 km | 2h 58m | G4 |
| Saint Petersburg | PIE | USA | 2,146 km | 3h 4m | G4 |
| Orlando | SFB | USA | 2,147 km | 3h 9m | G4 |
| Punta Gorda | PGD | USA | 2,276 km | 3h 16m | G4 |
| Fort Lauderdale | FLL | USA | 2,455 km | 3h 35m | G4 |