Enshi Airport offers nonstop service to 48 destinations, served by 8 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Wuhan | WUH | China | 457 km | 1h 10m | CZ, MU |
| Xian | XIY | China | 461 km | 1h 20m | GJ, JD |
| Chengdu | TFU | China | 484 km | 1h 20m | 9C |
| Guiyang | KWE | China | 494 km | 1h 15m | MU |
| Guangzhou | CAN | China | 856 km | 1h 58m | GJ |
| Nanning | NNG | China | 864 km | 2h 10m | JD |
| Kunming | KMG | China | 866 km | 1h 45m | DR |
| Taiyuan | TYN | China | 873 km | 2h 0m | PN |
| Lanzhou | LHW | China | 876 km | 2h 10m | GJ |
| Nanjing | NKG | China | 909 km | 1h 40m | JD |
| Yinchuan | INC | China | 931 km | 1h 45m | GJ |
| Shenzhen | SZX | China | 954 km | 2h 5m | GJ |
| Xining | XNN | China | 975 km | 2h 10m | GJ |
| Hong Kong | HKG | Hong Kong SAR | 992 km | 2h 15m | HB |
| Jinan | TNA | China | 1,018 km | 1h 50m | 9C |
| Hangzhou | HGH | China | 1,053 km | 2h 5m | GJ, JD |
| Wenzhou | WNZ | China | 1,137 km | 2h 5m | MU |
| Haikou | HAK | China | 1,154 km | 2h 10m | JD |
| Ningbo | NGB | China | 1,155 km | 2h 15m | GJ |
| Taizhou | HYN | China | 1,174 km | 2h 15m | MU |
| Shanghai | PVG | China | 1,183 km | 2h 15m | 9C |
| Qingdao | TAO | China | 1,191 km | 2h 50m | JD |
| Beijing | PKX | China | 1,198 km | 2h 20m | MU |
| Tianjin | TSN | China | 1,213 km | 2h 35m | DR |