Kefalonia offers nonstop service to 32 destinations, served by 21 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Zakinthos | ZTH | Greece | 52 km | 0h 25m | GQ |
| Preveza | PVK | Greece | 92 km | 0h 25m | GQ |
| Athens | ATH | Greece | 302 km | 1h 5m | GQ, A3 |
| Bari | BRI | Italy | 463 km | 1h 5m | V7 |
| Naples | NAP | Italy | 616 km | 1h 30m | V7, U2 |
| Rome | FCO | Italy | 814 km | 1h 40m | AZ, FR, W4 |
| Bucharest | OTP | Romania | 854 km | 1h 35m | A2, W4 |
| Timisoara | TSR | Romania | 857 km | 1h 40m | A2 |
| Pisa | PSA | Italy | 1,051 km | 1h 55m | FR |
| Vienna | VIE | Austria | 1,156 km | 2h 5m | OS, FR |
| Bolzano | BZO | Italy | 1,194 km | 2h 30m | BQ |
| Milan | BGY | Italy | 1,225 km | 2h 10m | FR |
| Milan | MXP | Italy | 1,283 km | 2h 15m | U2 |
| Munich | MUC | Germany | 1,337 km | 2h 15m | DE, 4Y |
| Prague | PRG | Czech Republic | 1,421 km | 2h 25m | QS |
| Zurich | ZRH | Switzerland | 1,421 km | 2h 30m | WK |
| Tel Aviv-Yafo | TLV | Israel | 1,473 km | 2h 25m | LY |
| Frankfurt | FRA | Germany | 1,629 km | 2h 40m | 4Y |
| Paris | ORY | France | 1,875 km | 3h 10m | TO |
| Amsterdam | AMS | Netherlands | 1,994 km | 3h 20m | HV, OR |
| London | LGW | United Kingdom | 2,174 km | 3h 40m | U2, LS |
| London | STN | United Kingdom | 2,196 km | 3h 30m | FR, LS |
| London | LHR | United Kingdom | 2,210 km | 3h 40m | BA |
| Bristol | BRS | United Kingdom | 2,339 km | 3h 38m | LS |
| Birmingham | BHX | United Kingdom | 2,344 km | 3h 50m | LS |
| Leicestershire | EMA | United Kingdom | 2,345 km | 3h 50m | LS |
| Manchester | MAN | United Kingdom | 2,432 km | 3h 55m | LS, U2 |
| Leeds | LBA | United Kingdom | 2,432 km | 3h 55m | LS |
| Newcastle | NCL | United Kingdom | 2,515 km | 3h 45m | LS |
| Oslo | OSL | Norway | 2,543 km | 3h 35m | DY |
| Edinburgh | EDI | United Kingdom | 2,660 km | 4h 15m | LS |
| Glasgow | GLA | United Kingdom | 2,707 km | 4h 15m | LS |