Durango International offers nonstop service to 11 destinations, served by 5 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Puerto Vallarta | PVR | Mexico | 388 km | 0h 55m | YQ |
| Guadalajara | GDL | Mexico | 418 km | 1h 9m | YQ, Y4 |
| Monterrey | MTY | Mexico | 481 km | 1h 10m | YQ, VB |
| Queretaro | QRO | Mexico | 591 km | 1h 16m | Y4 |
| Mexico City | NLU | Mexico | 746 km | 1h 30m | AM |
| Mexico City | MEX | Mexico | 766 km | 1h 45m | AM |
| Hermosillo | HMO | Mexico | 851 km | 1h 45m | YQ |
| Ciudad Juarez | CJS | Mexico | 853 km | 2h 0m | YQ |
| Dallas | DFW | USA | 1,216 km | 2h 10m | AA |
| Tijuana | TIJ | Mexico | 1,534 km | 2h 30m | Y4 |
| Chicago | MDW | USA | 2,500 km | 3h 31m | Y4 |