James M Cox Dayton International offers nonstop service to 28 destinations, served by 5 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Chicago | ORD | USA | 386 km | 1h 36m | AA, UA |
| Dulles | IAD | USA | 592 km | 1h 33m | UA |
| Charlotte | CLT | USA | 594 km | 1h 48m | AA |
| Washington | DCA | USA | 629 km | 1h 36m | AA |
| Raleigh/Durham | RDU | USA | 653 km | 1h 40m | MX |
| Atlanta | ATL | USA | 694 km | 1h 47m | DL |
| Philadelphia | PHL | USA | 767 km | 1h 43m | AA |
| Orlando | SFB | USA | 1,263 km | 2h 12m | G4 |
| Saint Petersburg | PIE | USA | 1,336 km | 2h 17m | G4 |
| Dallas | DFW | USA | 1,385 km | 2h 54m | AA |
| Punta Gorda | PGD | USA | 1,454 km | 2h 27m | G4 |
| Fort Myers | RSW | USA | 1,500 km | 2h 50m | MX |
| Fort Lauderdale | FLL | USA | 1,579 km | 2h 50m | MX |
| Denver | DEN | USA | 1,745 km | 3h 17m | UA |