Damascus International offers nonstop service to 46 destinations, served by 16 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Amman | AMM | Jordan | 193 km | 0h 50m | RJ |
| Deirezzor | DEZ | Syrian Arab Republic | 396 km | 1h 0m | RB |
| Baghdad | BGW | Iraq | 718 km | 1h 30m | |
| Erbil | EBL | Iraq | 749 km | 1h 30m | |
| Ankara | ESB | Turkiye | 807 km | 1h 40m | VF |
| Madinah | MED | Saudi Arabia | 1,030 km | 2h 0m | RB |
| Istanbul | SAW | Turkiye | 1,048 km | 2h 10m | VF |
| Istanbul | IST | Turkiye | 1,109 km | 2h 15m | RB, TK |
| Kuwait | KWI | Kuwait | 1,183 km | 2h 20m | J9, KU, RB |
| Jeddah | JED | Saudi Arabia | 1,326 km | 2h 25m | F3, RB, XY |
| Riyadh | RUH | Saudi Arabia | 1,362 km | 2h 28m | F3, RB, XY |
| Dammam | DMM | Saudi Arabia | 1,493 km | 2h 25m | XY |
| Bucharest | OTP | Romania | 1,530 km | 2h 45m | DN |
| Doha | DOH | Qatar | 1,719 km | 2h 40m | QR, RB |
| Abu Dhabi | AUH | United Arab Emirates | 2,024 km | 3h 10m | 3L, EY, RB |
| Dubai | DXB | United Arab Emirates | 2,037 km | 3h 10m | FZ, RB |
| Sharjah | SHJ | United Arab Emirates | 2,047 km | 3h 5m | G9, RB |
| Mitiga, Tripoli | MJI | Libya | 2,163 km | 3h 30m | |
| Muscat | MCT | Oman | 2,385 km | 3h 35m | OV |
| Moscow | SVO | Russia | 2,507 km | 4h 40m | RB |
| Copenhagen | CPH | Denmark | 3,080 km | 4h 40m | RB |
| Dusseldorf | DUS | Germany | 3,116 km | 4h 30m | KK |
| Amsterdam | AMS | Netherlands | 3,292 km | 5h 0m | RB |