Damascus International offers nonstop service to 17 destinations, served by 16 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Amman | AMM | Jordan | 193 km | 0h 50m | RJ |
| Erbil | EBL | Iraq | 749 km | 1h 30m | |
| Ankara | ESB | Turkiye | 807 km | 1h 43m | VF |
| Istanbul | SAW | Turkiye | 1,048 km | 2h 10m | VF |
| Istanbul | IST | Turkiye | 1,109 km | 2h 15m | TK |
| Kuwait | KWI | Kuwait | 1,183 km | 2h 10m | RB, J9 |
| Athens | ATH | Greece | 1,242 km | 2h 30m | MV |
| Jeddah | JED | Saudi Arabia | 1,326 km | 2h 20m | RB, XY, F3, SV |
| Riyadh | RUH | Saudi Arabia | 1,362 km | 2h 5m | XY, F3, SV |
| Tehran | IKA | Iran | 1,362 km | 1h 45m | |
| Dammam | DMM | Saudi Arabia | 1,493 km | 2h 20m | RB, XY |
| Bucharest | OTP | Romania | 1,530 km | 2h 55m | DN |
| Doha | DOH | Qatar | 1,719 km | 2h 40m | RB, QR |
| Abu Dhabi | AUH | United Arab Emirates | 2,024 km | 3h 5m | RB, 3L, EY |
| Dubai | DXB | United Arab Emirates | 2,037 km | 3h 10m | RB, FZ |
| Sharjah | SHJ | United Arab Emirates | 2,047 km | 3h 5m | RB, G9 |
| Muscat | MCT | Oman | 2,385 km | 3h 35m | OV |