Cozumel International offers nonstop service to 30 destinations, served by 11 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Cancun | CUN | Mexico | 58 km | 0h 40m | NO |
| Miami | MIA | USA | 897 km | 1h 44m | AA |
| Mexico City | NLU | Mexico | 1,266 km | 2h 10m | VB |
| Mexico City | MEX | Mexico | 1,276 km | 2h 27m | AM, Y4 |
| Houston | IAH | USA | 1,347 km | 2h 32m | UA |
| Monterrey | MTY | Mexico | 1,469 km | 2h 32m | VB |
| Atlanta | ATL | USA | 1,475 km | 2h 35m | DL |
| Dallas | DFW | USA | 1,699 km | 3h 11m | AA |
| Charlotte | CLT | USA | 1,732 km | 2h 54m | AA |
| Chicago | ORD | USA | 2,381 km | 3h 57m | AA, UA |
| Toronto | YYZ | Canada | 2,658 km | 4h 5m | AC, WS |
| Denver | DEN | USA | 2,730 km | 4h 24m | UA |
| Minneapolis | MSP | USA | 2,764 km | 4h 13m | DL, SY |
| Montreal | YUL | Canada | 3,019 km | 4h 15m | AC, TS |
| Calgary | YYC | Canada | 4,137 km | 6h 15m | WS |