Cozumel International offers nonstop service to 13 destinations, served by 10 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Miami | MIA | USA | 897 km | 1h 46m | AA |
| Mexico City | MEX | Mexico | 1,276 km | 2h 35m | Y4, AM |
| Houston | IAH | USA | 1,347 km | 2h 31m | UA |
| Monterrey | MTY | Mexico | 1,469 km | 2h 33m | VB |
| Atlanta | ATL | USA | 1,475 km | 2h 39m | DL |
| Dallas | DFW | USA | 1,699 km | 3h 13m | AA |
| Charlotte | CLT | USA | 1,732 km | 3h 0m | AA |
| Chicago | ORD | USA | 2,381 km | 3h 57m | AA, UA |
| Toronto | YYZ | Canada | 2,658 km | 4h 6m | AC, WS |
| Denver | DEN | USA | 2,730 km | 4h 24m | UA |
| Minneapolis | MSP | USA | 2,764 km | 4h 17m | DL, SY |
| Montreal | YUL | Canada | 3,019 km | 4h 10m | AC, TS |
| Calgary | YYC | Canada | 4,137 km | 6h 14m | WS |