Comiso Airport offers nonstop service to 10 destinations, served by 6 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Rome | FCO | Italy | 570 km | 1h 15m | W2, XZ |
| Tirana | TIA | Albania | 659 km | 1h 25m | W4 |
| Pisa | PSA | Italy | 825 km | 1h 40m | XZ, W2 |
| Bologna | BLQ | Italy | 881 km | 1h 40m | W2, XZ |
| Verona | VRN | Italy | 983 km | 1h 45m | V7, NO |
| Milan | LIN | Italy | 1,040 km | 1h 50m | XZ, W2 |
| Milan | MXP | Italy | 1,077 km | 1h 50m | NO |
| Turin | TRN | Italy | 1,081 km | 1h 55m | XZ, W2 |
| Paris | ORY | France | 1,639 km | 2h 45m | TO |
| Lille | LIL | France | 1,765 km | 2h 55m | V7 |