Ciampino offers nonstop service to 49 destinations, served by 2 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Cagliari | CAG | Italy | 411 km | 1h 5m | FR |
| Tirana | TIA | Albania | 595 km | 1h 25m | FR |
| Marseille | MRS | France | 631 km | 1h 25m | FR |
| Bratislava | BTS | Slovakia | 795 km | 1h 35m | FR |
| Budapest | BUD | Hungary | 819 km | 1h 40m | FR |
| Sofia | SOF | Bulgaria | 898 km | 1h 45m | FR |
| Prague | PRG | Czech Republic | 932 km | 1h 50m | FR |
| Lourdes | LDE | France | 1,045 km | 2h 0m | FR |
| Krakow | KRK | Poland | 1,075 km | 2h 0m | FR |
| Wroclaw | WRO | Poland | 1,085 km | 2h 5m | FR |
| Bucharest | OTP | Romania | 1,137 km | 2h 5m | FR |
| Brussels | CRL | Belgium | 1,148 km | 2h 10m | FR |
| Poznan | POZ | Poland | 1,222 km | 2h 10m | FR |
| Modlin | WMI | Poland | 1,330 km | 2h 15m | FR |
| London | STN | United Kingdom | 1,459 km | 2h 40m | FR, RK |
| Leicestershire | EMA | United Kingdom | 1,610 km | 2h 40m | FR |
| Manchester | MAN | United Kingdom | 1,697 km | 2h 50m | FR, RK |
| Vilnius | VNO | Lithuania | 1,705 km | 2h 45m | FR |
| Liverpool | LPL | United Kingdom | 1,723 km | 2h 50m | FR |
| Fes | FEZ | Morocco | 1,770 km | 2h 50m | FR |
| Rabat | RBA | Morocco | 1,900 km | 3h 10m | FR |
| Edinburgh | EDI | United Kingdom | 1,950 km | 3h 10m | FR, RK |
| Shannon | SNN | Ireland | 2,016 km | 3h 10m | FR |
| Marrakech | RAK | Morocco | 2,153 km | 3h 25m | FR |