Ciudad Obregon International offers nonstop service to 5 destinations, served by 3 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Tijuana | TIJ | Mexico | 894 km | 1h 38m | Y4 |
| Monterrey | MTY | Mexico | 984 km | 1h 50m | VB |
| Guadalajara | GDL | Mexico | 1,009 km | 1h 46m | Y4 |
| Mexico City | NLU | Mexico | 1,390 km | 2h 12m | VB |
| Mexico City | MEX | Mexico | 1,408 km | 2h 25m | AM |