Asyut International Airport offers nonstop service to 16 destinations, served by 8 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Sohag | HMB | Egypt | 107 km | 0h 45m | SM |
| Cairo | CAI | Egypt | 342 km | 1h 30m | SM |
| Tabuk | TUU | Saudi Arabia | 570 km | 1h 20m | SM |
| Amman | AMM | Jordan | 707 km | 1h 30m | SM, R5 |
| Amman | ADJ | Jordan | 727 km | 1h 35m | SM |
| Yanbu | YNB | Saudi Arabia | 778 km | 1h 35m | SM |
| Madinah | MED | Saudi Arabia | 914 km | 1h 45m | SM |
| Jouf | AJF | Saudi Arabia | 940 km | 1h 45m | SM |
| Jeddah | JED | Saudi Arabia | 1,018 km | 1h 50m | SM, XY, NE, F3 |
| Gassim | ELQ | Saudi Arabia | 1,271 km | 1h 55m | SM |
| Abha | AHB | Saudi Arabia | 1,543 km | 2h 15m | SM |
| Riyadh | RUH | Saudi Arabia | 1,586 km | 2h 25m | SM, XY, NE |
| Kuwait | KWI | Kuwait | 1,681 km | 2h 40m | J9, SM |
| Dammam | DMM | Saudi Arabia | 1,867 km | 2h 35m | SM |
| Abu Dhabi | AUH | United Arab Emirates | 2,385 km | 3h 55m | 3L |
| Sharjah | SHJ | United Arab Emirates | 2,453 km | 3h 20m | G9 |