Karpathos offers nonstop service to 19 destinations, served by 10 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Kasos Island | KSJ | Greece | 21 km | 0h 20m | OA |
| Rhodes | RHO | Greece | 138 km | 0h 45m | OA |
| Kos | KGS | Greece | 153 km | 0h 40m | NO |
| Athens | ATH | Greece | 399 km | 1h 15m | GQ, OA |
| Haifa | HFA | Israel | 783 km | 2h 0m | E2 |
| Naples | NAP | Italy | 1,277 km | 2h 15m | V7 |
| Rome | FCO | Italy | 1,474 km | 2h 35m | NO |
| Graz | GRZ | Austria | 1,613 km | 2h 25m | EW |
| Vienna | VIE | Austria | 1,658 km | 2h 35m | OS |
| Venice | VCE | Italy | 1,677 km | 2h 45m | V7 |
| Bologna | BLQ | Italy | 1,685 km | 2h 45m | NO |
| Verona | VRN | Italy | 1,762 km | 2h 55m | NO, V7 |
| Salzburg | SZG | Austria | 1,804 km | 2h 40m | EW |
| Innsbruck | INN | Austria | 1,857 km | 2h 45m | EW |
| Milan | BGY | Italy | 1,858 km | 2h 50m | NO |
| Milan | MXP | Italy | 1,922 km | 2h 55m | NO |
| Prague | PRG | Czech Republic | 1,936 km | 3h 5m | QS |
| Dusseldorf | DUS | Germany | 2,399 km | 3h 45m | EW |
| Amsterdam | AMS | Netherlands | 2,578 km | 4h 15m | OR, HV |