Santa Maria offers nonstop service to 16 destinations, served by 3 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Salvador | SSA | Brazil | 253 km | 0h 55m | AD, G3 |
| Recife | REC | Brazil | 394 km | 1h 20m | AD |
| Belo Horizonte | CNF | Brazil | 1,208 km | 2h 5m | AD |
| Brasilia | BSB | Brazil | 1,292 km | 2h 10m | LA |
| Rio De Janeiro | GIG | Brazil | 1,464 km | 2h 25m | G3 |
| Sao Paulo | GRU | Brazil | 1,700 km | 2h 45m | G3, LA |
| Campinas | VCP | Brazil | 1,707 km | 2h 45m | AD |
| Sao Paulo | CGH | Brazil | 1,729 km | 2h 50m | G3 |